Thrombotic microangiopathy secondary to VEGF pathway inhibition by sunitinib
نویسندگان
چکیده
منابع مشابه
Thrombotic microangiopathy associated with sunitinib, a VEGF inhibitor, in a patient with factor V Leiden mutation
Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are closely related disorders characterised by non-immune microangiopathic haemolytic anaemia and thrombocytopenia. Thrombotic microangiopathy is the underlying pathologic lesion in both syndromes. Under physiological conditions, platelets bind to endothelium via von Willebrand Factor (vWF) and are released back int...
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Sunitinib is an orally administered inhibitor of tyrosine kinases and has become the standard of care for many patients with metastatic renal cell carcinoma. Its use has been associated with renal toxicity in some patients. We report a patient with a metastatic clear-cell renal carcinoma who showed arterial hypertension, nephrotic syndrome and azotaemia 10 months after treatment with sunitinib....
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T thrombotic microangiopathy (TMA) represents a discreet group of disorders with common pathological features including fibrinoid necrosis, endothelial cell injury, and obstruction of vessels.1 The clinical presentation of TMA includes microangiopathic hemolytic anemia, thrombocytopenia, and functional impairment of various organ systems. Hemolytic uremic syndrome (HUS) and thrombotic thrombocy...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2008
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfn657